Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | ITK | Q08881 | 4/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 4/20 | 0.39 |
| ▸ | BCL6 | P41182 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 5/20 | 0.37 |
| ▸ | STK17B | O94768 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1028822 | 0.87 | CTSC (0.39) | CTSCEGFRITKBTKBCL6 | |
| SCHEMBL1026422 | 0.86 | BCL6 (0.38) | CTSCEGFRBTKBCL6STK17B | |
| SCHEMBL1026721 | 0.84 | JAK3 (0.42) | CTSCBCL6 | |
| SCHEMBL4360886 | 0.84 | CTSC (0.45) | CTSCEGFRITKBTKSYK | |
| SCHEMBL13623176 | 0.83 | EGFR (0.53) | CTSCEGFRITKBTKSYK | |
| SCHEMBL1026395 | 0.81 | BCL6 (0.40) | CTSCEGFRBTKBCL6STK17B | |
| SCHEMBL1028227 | 0.81 | MEN1 (0.42) | EGFRBTKSYK | |
| SCHEMBL1023285 | 0.80 | ALK (0.40) | BTKBCL6 | |
| SCHEMBL1028344 | 0.80 | F2 (0.40) | MAP3K5 | |
| SCHEMBL1026953 | 0.79 | GAA (0.47) | BTKBCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |