Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | UGCG | Q16739 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13562318 | 0.86 | HRH4 (0.67) | HRH4HRH3 | |
| SCHEMBL10263385 | 0.80 | HRH4 (0.74) | HRH4HRH3SIGMAR1F10HSP90AA1 | |
| SCHEMBL10263701 | 0.80 | HRH4 (0.69) | HRH4HRH3SIGMAR1F10HSP90AA1 | |
| SCHEMBL13562317 | 0.78 | ALOX15 (0.39) | HRH4SMN1; SMN2 | |
| SCHEMBL10263610 | 0.76 | HRH4 (0.49) | HRH4HRH3SIGMAR1F10HSP90AA1 | |
| SCHEMBL24159176 | 0.75 | MAP2K1 (0.37) | HRH4 | |
| SCHEMBL13562353 | 0.74 | HRH4 (0.47) | HRH4HRH3SIGMAR1F10HSP90AA1 | |
| SCHEMBL13562341 | 0.74 | HRH4 (0.47) | HRH4HRH3SIGMAR1F10HSP90AA1 | |
| SCHEMBL10263827 | 0.71 | HRH4 (0.47) | HRH4HRH3SIGMAR1 | |
| SCHEMBL10264407 | 0.70 | HRH4 (0.49) | HRH4HRH3SIGMAR1HSP90AA1RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2460794-A1 | PHARMACEUTICAL COMPOSITION CONTAINING FUSED HETERO-RING DERIVATIVE | Shionogi & Co., Ltd. (JP) | 2012-06-06 | — | — | EP | disclosed |