Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.30 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.30 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10249353 | 1.00 | IL1B (0.38) | IL1BTDP1PIM1PIM2SMN1; SMN2 | |
| SCHEMBL4071388 | 0.87 | TDP1 (0.36) | IL1BTDP1PIM1PIM2SMN1; SMN2 | |
| SCHEMBL516223 | 0.87 | TDP1 (0.36) | IL1BTDP1PIM1PIM2SMN1; SMN2 | |
| SCHEMBL195122 | 0.87 | TDP1 (0.36) | IL1BTDP1PIM1PIM2SMN1; SMN2 | |
| SCHEMBL10266291 | 0.75 | PIK3CA (0.37) | ALDH1A1MAPK1PDE7AKMT2A | |
| SCHEMBL4074985 | 0.74 | IL1B (0.37) | IL1BPIM1PIM2 | |
| SCHEMBL4078144 | 0.74 | IL1B (0.37) | IL1BPIM1PIM2 | |
| SCHEMBL15976821 | 0.73 | SCN9A (0.35) | IL1BPIM1PIM2 | |
| SCHEMBL8056169 | 0.72 | SYK (0.35) | IL1BALDH1A1POLBMAPK1HSD17B10 | |
| SCHEMBL15976836 | 0.72 | GPR119 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114878-B2 | 6,7-dihydrothieno[3,2-d]pyrimidine for the treatment of inflammatory diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-14 | — | — | US | disclosed |