Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL102666 | 0.77 | POLQ (0.39) | GRM5POLQFFAR1 | |
| SCHEMBL103738 | 0.77 | GRM5 (0.43) | GRM5FFAR1 | |
| SCHEMBL103391 | 0.76 | GRM5 (0.39) | GRM5 | |
| SCHEMBL105893 | 0.75 | GRM5 (0.39) | GRM5POLQFFAR1ALDH1A1 | |
| SCHEMBL103849 | 0.72 | GRM5 (0.36) | GRM5POLQFFAR1 | |
| SCHEMBL102032 | 0.71 | GRM5 (0.35) | GRM5POLQFFAR1ALDH1A1 | |
| SCHEMBL103737 | 0.70 | GRM5 (0.42) | GRM5POLQFFAR1ALDH1A1 | |
| SCHEMBL104380 | 0.69 | GRM5 (0.42) | GRM5POLQFFAR1ALDH1A1 | |
| SCHEMBL103836 | 0.68 | FFAR1 (0.58) | GRM5POLQFFAR1ALDH1A1 | |
| SCHEMBL103419 | 0.68 | ALDH1A1 (0.44) | GRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426115-A2 | Alkynyl derivatives as modulators of metabotropic glutamate receptors | Addex Pharma SA (CH) | 2012-03-07 | — | — | EP | disclosed |