Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | PPIA | P62937 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL103391 | 0.85 | GRM5 (0.39) | GRM5GRM4P2RY1 | |
| SCHEMBL103419 | 0.80 | ALDH1A1 (0.44) | GRM5HDAC3HDAC1POLBRAB9A | |
| SCHEMBL102005 | 0.79 | POLB (0.53) | GRM5PPIAHDAC3HDAC1POLB | |
| SCHEMBL102665 | 0.77 | GRM5 (0.36) | GRM5FFAR1 | |
| SCHEMBL101180 | 0.74 | GRM5 (0.53) | GRM5HDAC3HDAC1POLBRAB9A | |
| SCHEMBL103258 | 0.73 | KMT2A (0.51) | GRM5POLBRAB9A | |
| SCHEMBL103836 | 0.72 | FFAR1 (0.58) | GRM5FFAR1PTGDR2 | |
| SCHEMBL102995 | 0.71 | TSHR (0.52) | POLBRAB9A | |
| SCHEMBL5261892 | 0.70 | HDAC4 (0.53) | FFAR1HDAC3HDAC1RAB9A | |
| SCHEMBL105893 | 0.70 | GRM5 (0.39) | GRM5PPIAFFAR1PTGDR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426115-A2 | Alkynyl derivatives as modulators of metabotropic glutamate receptors | Addex Pharma SA (CH) | 2012-03-07 | — | — | EP | disclosed |
| EP-1765795-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharmaceuticals SA (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123703-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2005-12-29 | — | — | WO | disclosed |