Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17364602 | 0.86 | PDE4B (0.43) | SLC6A3SLC6A4HIF1ASLC6A2 | |
| SCHEMBL16432673 | 0.86 | PDE4B (0.43) | SLC6A3SLC6A4HIF1ASLC6A2 | |
| SCHEMBL27192119 | 0.85 | SLC6A2 (0.33) | SLC6A3SLC6A4HIF1ASLC6A2 | |
| SCHEMBL17364612 | 0.77 | HIF1A (0.33) | SLC6A3SLC6A4HIF1ASLC6A2 | |
| SCHEMBL17364609 | 0.77 | HIF1A (0.33) | SLC6A3SLC6A4HIF1ASLC6A2 | |
| SCHEMBL17365468 | 0.76 | PDE4B (0.38) | SLC6A3SLC6A4HIF1ASLC6A2 | |
| SCHEMBL17365509 | 0.76 | PDE4B (0.38) | SLC6A3SLC6A4HIF1ASLC6A2 | |
| SCHEMBL20073952 | 0.75 | SLC6A4 (0.41) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL2732428 | 0.75 | SLC6A3 (0.41) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL2732429 | 0.75 | SLC6A3 (0.41) | SLC6A3SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632269-B1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONES AS CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2017-03-15 | — | — | EP | disclosed |
| US-9221834-B2 | Cyclic amine substituted oxazolidinone CETP inhibitor | MERCK SHARP & DOHME CORP. (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221834-B2 | Cyclic amine substituted oxazolidinone CETP inhibitor | MERCK SHARP & DOHME CORP. (US) | 2015-12-29 | — | — | US | disclosed |
| WO-2012058187-A1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |