Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.32 |
| ▸ | CHRNG | P07510 | 2/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.32 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.32 |
| ▸ | CHRND | Q07001 | 2/20 | 0.32 |
| ▸ | MGLL | Q99685 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17364609 | 1.00 | HIF1A (0.33) | HIF1ASLC6A3SLC6A2SLC6A4CHRNB2 | |
| SCHEMBL17365509 | 0.87 | PDE4B (0.38) | HIF1ASLC6A3SLC6A2SLC6A4 | |
| SCHEMBL17365468 | 0.87 | PDE4B (0.38) | HIF1ASLC6A3SLC6A2SLC6A4 | |
| SCHEMBL17364615 | 0.83 | NR1H2 (0.35) | HIF1AGAAUCHL1 | |
| SCHEMBL17364614 | 0.83 | NR1H2 (0.35) | HIF1AGAAUCHL1 | |
| SCHEMBL24658424 | 0.81 | HIF1A (0.42) | HIF1A | |
| SCHEMBL17364611 | 0.79 | SLC6A3 (0.30) | SLC6A3 | |
| SCHEMBL17364613 | 0.79 | SLC6A3 (0.30) | SLC6A3 | |
| SCHEMBL17364602 | 0.77 | PDE4B (0.43) | HIF1ASLC6A3SLC6A2SLC6A4 | |
| SCHEMBL10267333 | 0.77 | SLC6A3 (0.36) | HIF1ASLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221834-B2 | Cyclic amine substituted oxazolidinone CETP inhibitor | MERCK SHARP & DOHME CORP. (US) | 2015-12-29 | — | — | US | disclosed |