Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1074594 | 0.87 | HSP90AA1 (0.32) | HSP90AA1JAK1JAK3AVPR1B | |
| SCHEMBL1023161 | 0.83 | HSP90AA1 (0.34) | HSP90AA1JAK1JAK3AVPR1BTTK | |
| SCHEMBL593155 | 0.82 | — | — | |
| SCHEMBL1027004 | 0.81 | HSP90AA1 (0.32) | HSP90AA1JAK1JAK3AVPR1BPIK3CA | |
| SCHEMBL6890894 | 0.80 | JAK1 (0.36) | HSP90AA1JAK1JAK3AVPR1BTTK | |
| SCHEMBL1073468 | 0.77 | JAK1 (0.37) | HSP90AA1JAK1JAK3PIK3CA | |
| SCHEMBL1082183 | 0.77 | JAK1 (0.34) | HSP90AA1JAK1JAK3AVPR1BTTK | |
| SCHEMBL2679521 | 0.76 | SMO (0.37) | HSP90AA1AVPR1BPIK3CA | |
| SCHEMBL584040 | 0.76 | ATR (0.41) | PIK3CA | |
| SCHEMBL7879162 | 0.76 | RAB9A (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002887-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | SCHERING CORPORATION (US) | 2011-01-06 | — | — | WO | disclosed |