Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.39 |
| ▸ | MAPT | P10636 | 11/20 | 0.39 |
| ▸ | NPC1 | O15118 | 9/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.36 |
| ▸ | STAT1 | P42224 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31339 | 0.90 | KDM4E (0.33) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL1083466 | 0.88 | AKR1C3 (0.32) | — | |
| SCHEMBL583888 | 0.88 | RAB9A (0.32) | RAB9AMAPTNPC1L3MBTL1KMT2A | |
| SCHEMBL12461451 | 0.85 | MAPT (0.41) | RAB9AMAPTNPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL584040 | 0.85 | ATR (0.41) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL10238601 | 0.84 | PDE10A (0.33) | RAB9AMAPTNPC1SMN1; SMN2KDM4E | |
| SCHEMBL584192 | 0.83 | HSP90AA1 (0.38) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL10238603 | 0.83 | PDE10A (0.32) | — | |
| SCHEMBL617633 | 0.83 | — | — | |
| SCHEMBL10280192 | 0.82 | CHRNB1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |