Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | WNK1 | Q9H4A3 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15174387 | 0.93 | MEN1 (0.49) | MEN1KMT2AMAPTMAPK1HCAR3 | |
| SCHEMBL30726366 | 0.93 | MEN1 (0.49) | MEN1KMT2AMAPTMAPK1HCAR3 | |
| SCHEMBL15740481 | 0.88 | MEN1 (0.53) | MEN1KMT2AMAPTMAPK1HCAR3 | |
| SCHEMBL15740508 | 0.88 | MEN1 (0.57) | MEN1KMT2AMAPTMAPK1HCAR3 | |
| SCHEMBL15740701 | 0.86 | KMT2A (0.59) | MEN1KMT2AMAPTMAPK1HCAR3 | |
| SCHEMBL30578514 | 0.86 | MEN1 (0.41) | MEN1KMT2AMAPTMAPK1HCAR3 | |
| SCHEMBL26774910 | 0.85 | BCL6 (0.47) | MEN1KMT2AMAPTMAPK1HCAR3 | |
| SCHEMBL572975 | 0.84 | HCAR3 (0.48) | MEN1KMT2AMAPTMAPK1HCAR3 | |
| SCHEMBL572153 | 0.84 | HCAR3 (0.48) | MEN1KMT2AMAPTMAPK1HCAR3 | |
| SCHEMBL572154 | 0.84 | HCAR3 (0.48) | MEN1KMT2AMAPTMAPK1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012018668-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2012-02-09 | — | — | WO | disclosed |