Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.36 |
| ▸ | APP | P05067 | 6/20 | 0.36 |
| ▸ | CTSD | P07339 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL882893 | 0.89 | BACE1 (0.36) | BACE1APPCTSDCYP2D6MKNK1 | |
| SCHEMBL10268804 | 0.86 | BACE1 (0.34) | BACE1APPCTSDCYP2D6MKNK1 | |
| SCHEMBL10266039 | 0.83 | BACE1 (0.35) | BACE1APPCTSDCYP2D6MKNK1 | |
| SCHEMBL882648 | 0.81 | BACE1 (0.35) | BACE1CTSD | |
| SCHEMBL882988 | 0.81 | BACE1 (0.32) | BACE1CTSD | |
| SCHEMBL882992 | 0.79 | CTSD (0.31) | BACE1CTSD | |
| SCHEMBL882991 | 0.77 | BACE1 (0.33) | BACE1CTSD | |
| SCHEMBL10265452 | 0.76 | BACE1 (0.34) | BACE1CTSD | |
| SCHEMBL10266487 | 0.76 | BACE1 (0.35) | BACE1CTSD | |
| SCHEMBL10266405 | 0.73 | BACE1 (0.32) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040641-A2 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2012-03-29 | — | — | WO | disclosed |