Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 4/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.57 |
| ▸ | IGF1R | P08069 | 2/20 | 0.57 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.57 |
| ▸ | IKBKB | O14920 | 2/20 | 0.57 |
| ▸ | CHUK | O15111 | 2/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | PAK4 | O96013 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.57 |
| ▸ | LTK | P29376 | 1/20 | 0.57 |
| ▸ | GRK5 | P34947 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2240671 | 0.82 | AURKB (0.71) | PRKCIAURKBIGF1RDYRK1BIKBKB | |
| SCHEMBL4793014 | 0.82 | IGF1R (0.63) | PRKCIAURKBIGF1RDYRK1BIKBKB | |
| SCHEMBL2601269 | 0.81 | TGFBR1 (0.60) | PRKCIAURKBIGF1RDYRK1BIKBKB | |
| SCHEMBL26174482 | 0.80 | DYRK1B (0.63) | PRKCIAURKBIGF1RDYRK1BIKBKB | |
| SCHEMBL14494199 | 0.79 | NUDT1 (0.58) | PRKCIAURKBIGF1RDYRK1BIKBKB | |
| SCHEMBL10125139 | 0.78 | PRKCI (0.55) | PRKCIAURKBIGF1RDYRK1BIKBKB | |
| SCHEMBL12127272 | 0.78 | PRKCI (0.67) | PRKCIAURKBIGF1RDYRK1BIKBKB | |
| SCHEMBL29789047 | 0.78 | PRKCI (0.67) | PRKCIAURKBIGF1RDYRK1BIKBKB | |
| SCHEMBL1840342 | 0.77 | IGF1R (0.60) | PRKCIAURKBIGF1RDYRK1BIKBKB | |
| SCHEMBL581274 | 0.76 | NUDT1 (0.57) | JAK2PRKCQROCK1NUDT1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |