Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1025124 | 0.83 | ALDH1A1 (0.46) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL1025121 | 0.83 | ALDH1A1 (0.46) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL1024587 | 0.80 | KMT2A (0.40) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL13622730 | 0.79 | ALOX5 (0.48) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL1024716 | 0.73 | KMT2A (0.42) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL1024715 | 0.73 | KMT2A (0.42) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL1027383 | 0.72 | ALDH1A1 (0.65) | MEN1KMT2AMAPTALDH1A1ALOX5 | |
| SCHEMBL1027384 | 0.72 | ALDH1A1 (0.65) | MEN1KMT2AMAPTALDH1A1ALOX5 | |
| SCHEMBL2453170 | 0.72 | TP53 (0.49) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL2453168 | 0.72 | TP53 (0.49) | MEN1KMT2AMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |