Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717865 | 0.74 | CA12 (0.39) | HTTALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL31124347 | 0.63 | TDP1 (0.45) | HTTTDP1MEN1KMT2ALMNA | |
| SCHEMBL14645261 | 0.62 | TDP1 (0.54) | ALDH1A1TDP1MEN1KMT2AGAA | |
| SCHEMBL24439643 | 0.61 | DYRK1A (0.46) | HTTTDP1MEN1KMT2ALMNA | |
| SCHEMBL569251 | 0.61 | TDP1 (0.74) | HTTALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL3020258 | 0.61 | TDP1 (0.81) | HTTTDP1MEN1KMT2AGAA | |
| SCHEMBL3154615 | 0.61 | TDP1 (0.51) | TDP1MEN1KMT2AGAADRD2 | |
| SCHEMBL1519817 | 0.61 | MEN1 (0.60) | TDP1MEN1KMT2AGAA | |
| SCHEMBL4755907 | 0.61 | TDP1 (0.48) | ALDH1A1TDP1MEN1KMT2ADYRK1A | |
| SCHEMBL30987435 | 0.60 | CNR2 (0.50) | DYRK1ADRD2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |