SCHEMBL10272080 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	SYK	P43405	8/20	0.64

▸	AURKA	O14965	2/20	0.53

▸	PIP4K2A	P48426	5/20	0.40

▸	TNIK	Q9UKE5	1/20	0.40

▸	NPC1	O15118	1/20	0.39

▸	RAB9A	P51151	1/20	0.39

▸	JAK2	O60674	2/20	0.38

▸	JAK1	P23458	1/20	0.38

▸	JAK3	P52333	1/20	0.38

▸	PTK2	Q05397	1/20	0.38

▸	BTK	Q06187	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10272079	0.88	SYK (0.70)	SYKAURKATNIKNPC1RAB9A
SCHEMBL10272206	0.87	SYK (0.48)	SYKAURKATNIKNPC1RAB9A
SCHEMBL2716777	0.85	PIP4K2A (0.48)	SYKAURKAPIP4K2A
SCHEMBL2716765	0.85	PIP4K2A (0.48)	SYKAURKAPIP4K2A
SCHEMBL10272082	0.83	SYK (0.43)	SYKAURKAPIP4K2A
SCHEMBL2715096	0.78	SYK (0.61)	SYKAURKAPIP4K2ANPC1RAB9A
SCHEMBL9107210	0.78	SYK (0.61)	SYKAURKAPIP4K2ANPC1RAB9A
SCHEMBL1354375	0.78	SYK (1.00)	SYK
SCHEMBL16743177	0.78	SYK (0.74)	SYKAURKATNIKBTK
SCHEMBL1354369	0.78	SYK (1.00)	SYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2012061415-A1	OXYPYRIMIDINES AS SYK MODULATORS	PORTOLA PHARMACEUTICALS, INC. (US)	2012-05-10	—	—	WO	disclosed