Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | PIP4K2A | P48426 | 8/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272087 | 0.89 | SYK (0.47) | SYKAURKA | |
| SCHEMBL10272080 | 0.83 | SYK (0.64) | SYKAURKAPIP4K2A | |
| SCHEMBL2718505 | 0.74 | SYK (0.33) | SYK | |
| SCHEMBL2717347 | 0.73 | SYK (0.49) | SYK | |
| SCHEMBL2723066 | 0.73 | SYK (0.51) | SYKPIP4K2AKDM4E | |
| SCHEMBL2723063 | 0.73 | SYK (0.51) | SYKPIP4K2AKDM4E | |
| SCHEMBL16743200 | 0.71 | SYK (0.47) | SYK | |
| SCHEMBL2717000 | 0.71 | SYK (0.53) | SYK | |
| SCHEMBL10272079 | 0.71 | SYK (0.70) | SYKAURKA | |
| SCHEMBL10272206 | 0.70 | SYK (0.48) | SYKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |