Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272082 | 0.89 | SYK (0.43) | SYKAURKA | |
| SCHEMBL2718505 | 0.85 | SYK (0.33) | SYKMEN1KMT2A | |
| SCHEMBL10272079 | 0.82 | SYK (0.70) | SYKAURKA | |
| SCHEMBL2718497 | 0.80 | MEN1 (0.33) | SYKMEN1KMT2A | |
| SCHEMBL2718499 | 0.80 | MEN1 (0.33) | SYKMEN1KMT2A | |
| SCHEMBL2717581 | 0.77 | MEN1 (0.31) | MEN1KMT2A | |
| SCHEMBL2717582 | 0.77 | MEN1 (0.31) | MEN1KMT2A | |
| SCHEMBL16743200 | 0.75 | SYK (0.47) | SYK | |
| SCHEMBL2717525 | 0.72 | SYK (0.56) | SYK | |
| SCHEMBL2717527 | 0.72 | SYK (0.56) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |