Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732646 | 0.87 | CYP1A2 (0.53) | MAPTHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL2733568 | 0.78 | MAPT (0.61) | MAPTPKMCTDSP1HPGDALDH1A1 | |
| SCHEMBL10687158 | 0.77 | NPC1 (0.79) | MAPTPKMCTDSP1HPGDALDH1A1 | |
| SCHEMBL8291917 | 0.75 | ALOX5 (0.64) | MAPTALDH1A1SMN1; SMN2HDAC1TP53 | |
| SCHEMBL211295 | 0.73 | ALOX5 (0.67) | MAPTALDH1A1SMN1; SMN2HDAC1TP53 | |
| SCHEMBL214248 | 0.70 | MAPT (0.53) | MAPTPKMCTDSP1HPGDALDH1A1 | |
| SCHEMBL211621 | 0.70 | MAPT (0.67) | MAPTPKMCTDSP1HPGDALDH1A1 | |
| SCHEMBL8359674 | 0.67 | MAOB (0.56) | MAPTPKMCTDSP1HPGDALDH1A1 | |
| SCHEMBL9393839 | 0.67 | SMN1; SMN2 (0.55) | HPGDALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL211118 | 0.67 | HSD17B10 (0.57) | NPC1RAB9AKMT2AMEN1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088805-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-01-03 | — | — | US | disclosed |