Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.67 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.51 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.51 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.48 |
| ▸ | GCGR | P47871 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8291917 | 0.95 | ALOX5 (0.64) | ALOX5EPHX2CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL210929 | 0.91 | ALOX5 (0.72) | ALOX5EPHX2CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL212212 | 0.83 | MAPT (0.56) | ALOX5EPHX2CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL8659490 | 0.82 | OPRL1 (0.49) | ALOX5EPHX2CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL211608 | 0.81 | HDAC1 (0.73) | ALOX5EPHX2MAPTALDH1A1HDAC3 | |
| SCHEMBL12963079 | 0.79 | OPRL1 (0.60) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL8291911 | 0.78 | SMN1; SMN2 (0.46) | ALOX5EPHX2CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL210356 | 0.78 | CYP2E1 (0.74) | ALOX5EPHX2CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL10691877 | 0.77 | ALDH1A1 (0.75) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL210572 | 0.76 | ALOX5 (0.61) | ALOX5EPHX2CYP1A2CYP2E1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088805-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-01-03 | — | — | US | disclosed |
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | METHYLGENE INC. (CA) | 2007-09-13 | — | — | US | disclosed |
| US-7253204-B2 | Antiproliferative agents | METHYLGENE INC. (CA) | 2007-08-07 | — | — | US | disclosed |
| EP-1735319-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2006-12-27 | — | — | EP | disclosed |
| US-20050245518-A1 | Antiproliferative agents | METHYLGENE, INC. | 2005-11-03 | — | — | US | disclosed |
| WO-2005092899-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | HDAC1, HDAC11, HDAC5 | ALOX5 3601/4885EPHX2 3444/4885CYP1A2 4230/4885 |
| US-20050245518-A1 | Antiproliferative agents | HDAC1, HDAC11, HDAC5 | ALOX5 3075/4885EPHX2 3151/4885CYP1A2 4311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.