Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PMM2 | O15305 | 2/20 | 0.37 |
| ▸ | MIF | P14174 | 2/20 | 0.37 |
| ▸ | MPI | P34949 | 2/20 | 0.37 |
| ▸ | PHOSPHO1 | Q8TCT1 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068558 | 0.64 | CYP2C19 (0.55) | NPC1RAB9AALDH1A1MAPK14NPSR1 | |
| SCHEMBL29463693 | 0.64 | NPC1 (0.48) | NPC1RAB9AAMY1A | |
| SCHEMBL22443378 | 0.64 | NPC1 (0.48) | NPC1RAB9AAMY1A | |
| SCHEMBL27964264 | 0.63 | ALOX5AP (0.45) | NPC1RAB9AMAOBGAAAMY1A | |
| SCHEMBL10276472 | 0.62 | PMM2 (0.39) | PMM2MIFMPIPHOSPHO1NPC1 | |
| SCHEMBL10275560 | 0.62 | PDE4A (0.47) | PMM2MIFMPIPHOSPHO1NPC1 | |
| SCHEMBL10275658 | 0.62 | HPGD (0.46) | NPC1RAB9AALDH1A1ARMAPT | |
| SCHEMBL10275559 | 0.61 | PMM2 (0.38) | PMM2MIFMPIPHOSPHO1NPC1 | |
| SCHEMBL549169 | 0.61 | POLB (0.51) | PMM2MIFMPIPHOSPHO1MAPK14 | |
| SCHEMBL4777615 | 0.61 | CHRNA7 (0.42) | ALDH1A1NPSR1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | PMM2 1860/4885MIF 4872/4885MPI 830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.