Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PMM2 | O15305 | 2/20 | 0.38 |
| ▸ | MIF | P14174 | 2/20 | 0.38 |
| ▸ | MPI | P34949 | 2/20 | 0.38 |
| ▸ | PHOSPHO1 | Q8TCT1 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10275560 | 0.65 | PDE4A (0.47) | PMM2MIFMPIPHOSPHO1NPC1 | |
| SCHEMBL6068558 | 0.64 | CYP2C19 (0.55) | NPC1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL13152153 | 0.63 | PMM2 (0.46) | PMM2MIFMPIPHOSPHO1NPC1 | |
| SCHEMBL10275232 | 0.61 | PMM2 (0.37) | PMM2MIFMPIPHOSPHO1NPC1 | |
| SCHEMBL27093095 | 0.61 | MAPK14 (0.38) | MAPTGAAL3MBTL1 | |
| SCHEMBL2710033 | 0.61 | APP (0.40) | NPC1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL2726616 | 0.61 | ACHE (0.47) | ALDH1A1MAPTLMNAHTTKDM4E | |
| SCHEMBL10275360 | 0.61 | AR (0.40) | NPC1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL10276472 | 0.61 | PMM2 (0.39) | PMM2MIFMPIPHOSPHO1NPC1 | |
| SCHEMBL28854556 | 0.61 | ALDH1A1 (0.46) | PMM2MIFMPIPHOSPHO1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | PMM2 1860/4885MIF 4872/4885MPI 830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.