Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10275638 | 0.82 | KCNH2 (0.36) | KCNH2FNTAFNTBPGGT1BMAPK14 | |
| SCHEMBL10313880 | 0.78 | BRD4 (0.38) | KCNH2MAPK14 | |
| SCHEMBL10275678 | 0.78 | BRD4 (0.39) | KCNH2MAPK14 | |
| SCHEMBL10275941 | 0.72 | MDM2 (0.34) | KCNH2FNTAFNTBPGGT1BMAPK14 | |
| SCHEMBL10276004 | 0.72 | KCNH2 (0.37) | KCNH2FNTAFNTBPGGT1BMAPK14 | |
| SCHEMBL10275694 | 0.71 | TDP2 (0.35) | — | |
| SCHEMBL10276350 | 0.70 | PDE3B (0.34) | KCNH2 | |
| SCHEMBL10276333 | 0.70 | ADORA1 (0.33) | KCNH2FNTAFNTBPGGT1B | |
| SCHEMBL10275499 | 0.69 | KDM1A (0.38) | KCNH2 | |
| SCHEMBL10276290 | 0.66 | FNTA (0.34) | KCNH2FNTAFNTBPGGT1BMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | KCNH2 1984/4885FNTA 3998/4885FNTB 3608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.