Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARF6 | P62330 | 8/20 | 0.46 |
| ▸ | FLT3 | P36888 | 5/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10275539 | 0.86 | FLT3 (0.39) | ARF6FLT3PDE3BPDE3AALK | |
| SCHEMBL10276044 | 0.84 | PLAT (0.40) | ARF6FLT3PLAT | |
| SCHEMBL10276262 | 0.84 | ARF6 (0.49) | ARF6FLT3PDE3BPDE3APLAT | |
| SCHEMBL10275156 | 0.83 | ARF6 (0.45) | ARF6KDM1APDE3BPDE3APLAT | |
| SCHEMBL10275869 | 0.83 | FLT3 (0.38) | ARF6FLT3PDE3BPDE3AALK | |
| SCHEMBL10275663 | 0.82 | ARF6 (0.47) | ARF6KDM1APDE3BPDE3APLAT | |
| SCHEMBL10275306 | 0.79 | ARF6 (0.43) | ARF6KDM1APLAT | |
| SCHEMBL10275650 | 0.78 | FLT3 (0.38) | FLT3KDM1APDE3BPDE3APARP1 | |
| SCHEMBL10275454 | 0.75 | KDM1A (0.41) | ARF6KDM1A | |
| SCHEMBL10276164 | 0.74 | ARF6 (0.41) | ARF6KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554111-A | Aromatic heterocyclic pyridine derivatives and analogs, and preparation method and application thereof | LIAONING LIFENG SCIENCE AND TECHNOLOGY DEV CO LTD | 2014-02-05 | — | — | CN | claimed |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | claimed |
| CN-103554111-A | Aromatic heterocyclic pyridine derivatives and analogs, and preparation method and application thereof | LIAONING LIFENG SCIENCE AND TECHNOLOGY DEV CO LTD | 2014-02-05 | — | — | CN | disclosed |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | disclosed |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | disclosed |
| WO-2011035518-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | 辽宁利锋科技开发有限公司 (CN) | 2011-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | ARF6 3355/4885FLT3 780/4885KDM1A 3996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.