Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 10/20 | 0.34 |
| ▸ | FEN1 | P39748 | 10/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10276696 | 0.90 | KIF11 (0.34) | ALOX5APFEN1PDE3BPDE3A | |
| SCHEMBL10276335 | 0.87 | PDE3B (0.36) | ALOX5APFEN1PDE3BPDE3A | |
| SCHEMBL10276411 | 0.86 | APP (0.36) | ALOX5APFEN1APPAKR1C3AKR1C2 | |
| SCHEMBL10275483 | 0.85 | ALOX5AP (0.34) | ALOX5APFEN1APPAKR1C3AKR1C2 | |
| SCHEMBL10275775 | 0.81 | ALOX5AP (0.33) | ALOX5APFEN1APPAKR1C3AKR1C2 | |
| SCHEMBL10276352 | 0.77 | PDE3B (0.36) | ALOX5APFEN1PDE3BPDE3ATDP2 | |
| SCHEMBL10275697 | 0.75 | PDE3B (0.34) | BACE1ALOX5APFEN1APPPDE3B | |
| SCHEMBL10276045 | 0.73 | APP (0.35) | APPTDP2 | |
| SCHEMBL10275868 | 0.73 | RAD51 (0.33) | BACE1TDP2 | |
| SCHEMBL10275642 | 0.73 | PDE3B (0.37) | ALOX5APFEN1PDE3BPDE3ATDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | BACE1 47/4885ALOX5AP 1631/4885FEN1 1832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.