Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10313600 | 0.89 | SLC11A2 (0.42) | ARNPC1TP53MAPTRAB9A | |
| SCHEMBL10275292 | 0.82 | KIF11 (0.46) | — | |
| SCHEMBL10275326 | 0.82 | AR (0.46) | ARNPC1TP53MAPTRAB9A | |
| SCHEMBL10275928 | 0.75 | DPP4 (0.44) | ARKMT2A | |
| SCHEMBL23832274 | 0.71 | AR (0.43) | ARNPC1TP53MAPTRAB9A | |
| SCHEMBL10275284 | 0.71 | SLC11A2 (0.40) | NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL3070064 | 0.70 | AR (0.65) | ARNPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL10313601 | 0.70 | ATM (0.40) | ARNPC1TP53MAPTRAB9A | |
| SCHEMBL23845621 | 0.70 | AR (0.42) | ARNPC1TP53MAPTRAB9A | |
| SCHEMBL27815952 | 0.69 | AR (0.56) | ARMAP4K4NR3C2GRIA2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554111-A | Aromatic heterocyclic pyridine derivatives and analogs, and preparation method and application thereof | LIAONING LIFENG SCIENCE AND TECHNOLOGY DEV CO LTD | 2014-02-05 | — | — | CN | claimed |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | claimed |
| CN-101671336-A | Aromatic heterocyclic pyrimidine derivative and analogue, preparation method and application thereof | LIAONING LIFENG SCIENCE AND TE | 2010-03-17 | — | — | CN | claimed |
| CN-103554111-A | Aromatic heterocyclic pyridine derivatives and analogs, and preparation method and application thereof | LIAONING LIFENG SCIENCE AND TECHNOLOGY DEV CO LTD | 2014-02-05 | — | — | CN | disclosed |
| CN-101671336-B | Aromatic heterocyclic pyrimidine derivative and analogue, preparation method and application thereof | LIAONING LIFENG SCIENCE AND TECHNOLOGY DEV CO LTD | 2013-11-13 | — | — | CN | disclosed |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | disclosed |
| WO-2011035518-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | 辽宁利锋科技开发有限公司 (CN) | 2011-03-31 | — | — | WO | disclosed |
| CN-101671336-A | Aromatic heterocyclic pyrimidine derivative and analogue, preparation method and application thereof | LIAONING LIFENG SCIENCE AND TE | 2010-03-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | AR 3221/4885NPC1 1381/4885TP53 2161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.