Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 6/20 | 0.54 |
| ▸ | PDE4A | P27815 | 3/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1027709 | 1.00 | PDE4D (0.54) | PDE4DPDE4APDE4BPDE4CNPC1 | |
| SCHEMBL1026451 | 0.92 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CNPC1 | |
| SCHEMBL1026450 | 0.92 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CNPC1 | |
| SCHEMBL1081724 | 0.90 | PDE4A (0.55) | PDE4DPDE4APDE4BPDE4CSMPD1 | |
| SCHEMBL1032137 | 0.84 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CNPC1 | |
| SCHEMBL1032139 | 0.84 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CNPC1 | |
| SCHEMBL1030400 | 0.83 | PDE4B (0.77) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1030398 | 0.83 | PDE4B (0.77) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL4881516 | 0.82 | ALDH1A1 (0.48) | PDE4DPDE4APDE4BPDE4CNPC1 | |
| SCHEMBL1029620 | 0.82 | PDE4B (0.78) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044023-B1 | DERIVATIVES OF 1-PHENYL-2-PYRIDYNYL ALKYLENE ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMA SPA (IT) | 2011-01-19 | — | — | EP | disclosed |