Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.46 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10230682 | 1.00 | KDM4E (0.58) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2GRIN1 | |
| SCHEMBL10232539 | 1.00 | KDM4E (0.58) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2GRIN1 | |
| SCHEMBL917841 | 0.87 | GRIN1 (0.66) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2GRIN1 | |
| SCHEMBL9132268 | 0.86 | GRIN1 (0.64) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2GRIN1 | |
| SCHEMBL20689722 | 0.85 | KDM4E (0.73) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2GRIN1 | |
| SCHEMBL8446901 | 0.82 | GRIN1 (0.49) | GRIN1GRIN2A | |
| SCHEMBL7298568 | 0.81 | KDM4E (0.61) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2GRIN1 | |
| SCHEMBL354130 | 0.81 | GRIN1 (0.45) | KDM4EALDH1A1SMN1; SMN2GRIN1GRIN2A | |
| SCHEMBL7075226 | 0.80 | RIPK1 (0.47) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2AOC3 | |
| SCHEMBL7076936 | 0.80 | RIPK1 (0.47) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140329746-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2014-11-06 | — | — | US | disclosed |
| US-8835654-B2 | Method and compositions for treating amyloid-related diseases | BHI LIMITED PARTNERSHIP (CA) | 2014-09-16 | — | — | US | disclosed |
| US-20120015911-A1 | METHOD AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | BELLUS HEALTH INC. (CA) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329746-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | APP, PSEN1, PSEN2 | KDM4E 4713/4885L3MBTL1 3626/4885ALDH1A1 2989/4885 |
| US-20120015911-A1 | METHOD AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | APP, PSEN1, PSEN2 | KDM4E 4793/4885L3MBTL1 3852/4885ALDH1A1 3131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.