Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7075226 | 1.00 | RIPK1 (0.47) | RIPK1LMNAALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL972987 | 1.00 | RIPK1 (0.47) | RIPK1LMNAALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL11644157 | 0.90 | LMNA (0.52) | RIPK1LMNAALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL7320028 | 0.86 | HRH1 (0.50) | ALDH1A1SRCCYP2C19 | |
| SCHEMBL3139395 | 0.81 | SRC (0.39) | LMNAALDH1A1KDM4ESRCGMNN | |
| SCHEMBL3129720 | 0.81 | CYP2C19 (0.41) | LMNAALDH1A1KDM4ESRCGMNN | |
| SCHEMBL3129679 | 0.81 | SRC (0.39) | LMNAALDH1A1KDM4ESRCGMNN | |
| SCHEMBL3139496 | 0.81 | SRC (0.39) | LMNAALDH1A1KDM4ESRCGMNN | |
| SCHEMBL9875298 | 0.81 | HRH1 (0.48) | ALDH1A1SRCCYP2C19 | |
| SCHEMBL10277987 | 0.80 | KDM4E (0.58) | LMNAALDH1A1KDM4EL3MBTL1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612242-B1 | USE OF THE PURE S(+) ISOMER OF FLUOXETINE FOR THE PREPARATION OF A MEDICAMENT AGAINST MIGRAINE HEADACHE | SEPRACOR INC (US) | 2003-07-09 | — | — | EP | disclosed |
| EP-1208838-A2 | Pure S(+)isomer fluoxetine | Sepracor Inc. (US) | 2002-05-29 | — | — | EP | disclosed |
| US-5708035-A | ANTIDEPRESSANTS, APPETITE SUPPRESSANTS, TREATMENT OF PAIN, SUBSTANCE ABUSE, OBSESSIVE-COMPULSIVE DISORDERS | SEPRACOR INC. (US) | 1998-01-13 | — | — | US | disclosed |
| US-5648396-A | Methods for treating depression and other disorders using optically pure R (-) fluoxetine and monoamine oxidase inhibitor | SEPRACOR INC. (US) | 1997-07-15 | — | — | US | disclosed |
| EP-0612242-A4 | METHODS AND COMPOSITIONS UTILIZING PURE S(+) ISOMER FLUOXETINE. | SEPRACOR INC (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5589511-A | Method for treating migraine headaches using optically pure S(+) fluoxetine | SEPRACOR INC. (US) | 1996-12-31 | — | — | US | disclosed |
| WO-1995028152-A1 | METHODS AND COMPOSITIONS FOR TREATING DEPRESSION AND OTHER DISORDERS USING OPTICALLY PURE S(+) FLUOXETINE | SEPRACOR INC. (US) | 1995-10-26 | — | — | WO | disclosed |
| EP-0612242-A1 | METHODS AND COMPOSITIONS UTILIZING PURE S(+) ISOMER FLUOXETINE | SEPRACOR, INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993009769-A1 | METHODS AND COMPOSITIONS UTILIZING PURE S(+) ISOMER FLUOXETINE | SEPRACOR, INC. (US) | 1993-05-27 | — | — | WO | disclosed |
| WO-1992013452-A1 | METHODS OF USE AND COMPOSITIONS OF R(-) FLUOXETINE | YOUNG JAMES W (US) | 1992-08-20 | — | — | WO | disclosed |
| US-5104899-A | Side effect reduction | SEPRACOR, INC. (US) | 1992-04-14 | — | — | US | disclosed |