Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 16/20 | 0.46 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.46 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL501088 | 0.90 | HSP90AA1 (0.48) | PDK1HSP90AA1HSP90B1TRAP1HSP90AB1 | |
| SCHEMBL501196 | 0.89 | HSP90AA1 (0.55) | PDK1HSP90AA1HSP90B1TRAP1HSP90AB1 | |
| SCHEMBL501485 | 0.87 | HSP90AA1 (0.52) | PDK1HSP90AA1HSP90B1TRAP1HSP90AB1 | |
| SCHEMBL501013 | 0.87 | PDK1 (0.59) | PDK1HSP90AA1HSP90B1TRAP1HSP90AB1 | |
| SCHEMBL501080 | 0.87 | HSP90AA1 (0.46) | PDK1HSP90AA1HSP90B1TRAP1HSP90AB1 | |
| SCHEMBL13477647 | 0.82 | PDK1 (0.46) | PDK1HSP90AA1HSP90B1TRAP1HSP90AB1 | |
| SCHEMBL13477618 | 0.82 | ALDH1A1 (0.41) | HSP90AA1HSP90B1HSP90AB1IDO1TDO2 | |
| SCHEMBL501687 | 0.81 | HSP90AA1 (0.47) | PDK1HSP90AA1HSP90B1TRAP1HSP90AB1 | |
| SCHEMBL501493 | 0.80 | HSP90AA1 (0.41) | PDK1HSP90AA1HSP90B1TRAP1HSP90AB1 | |
| SCHEMBL501079 | 0.80 | HSP90AA1 (0.45) | PDK1HSP90AA1HSP90B1TRAP1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106083-B2 | Triazole compounds that modulate HSP90 activity | SYNTA PHARMACEUTICALS CORP. (US) | 2012-01-31 | — | — | US | disclosed |
| US-20100113447-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113447-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | HSP90AB1, HSP90B1, HSP90AA1 | PDK1 1289/4885HSP90AA1 3/4885HSP90B1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.