Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9928745 | 0.91 | CSNK1E (0.41) | NQO2PTPN11CSNK1EJAK2TRPM8 | |
| SCHEMBL15621481 | 0.84 | TRPM8 (0.40) | TRPM8ALDH1A1KMT2ASMN1; SMN2GPBAR1 | |
| SCHEMBL2013729 | 0.84 | TRPM8 (0.38) | NQO2PTPN11TRPM8ALDH1A1KMT2A | |
| SCHEMBL9928695 | 0.81 | TRPM8 (0.38) | TRPM8ALDH1A1KMT2AGPBAR1DHODH | |
| SCHEMBL10278679 | 0.80 | PIK3CD (0.38) | NQO2PTPN11CSNK1EALDH1A1F10 | |
| SCHEMBL18935627 | 0.79 | RELA (0.38) | TRPM8ALDH1A1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL22048112 | 0.79 | TRPM8 (0.36) | TRPM8ALDH1A1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL9929195 | 0.78 | POLB (0.33) | DHODH | |
| SCHEMBL9928939 | 0.78 | DHODH (0.36) | PTPN11TRPM8ALDH1A1KMT2AGPBAR1 | |
| SCHEMBL2014204 | 0.78 | PIK3CD (0.44) | TRPM8ALDH1A1KMT2ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660016-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Holdings Corporation (US) | 2020-06-03 | — | — | EP | disclosed |
| EP-2655374-B1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE HOLDINGS CORP (US) | 2019-10-23 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |