Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL319625 | 0.97 | MEN1 (0.35) | MEN1KMT2AHTTALDH1A1PRKCQ | |
| SCHEMBL1911232 | 0.81 | ALDH1A1 (0.34) | MEN1KMT2AHTTALDH1A1KDM4E | |
| SCHEMBL1911241 | 0.81 | MEN1 (0.33) | MEN1KMT2AHTTALDH1A1KDM4E | |
| SCHEMBL1910714 | 0.80 | MEN1 (0.37) | MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL319340 | 0.80 | ALDH1A1 (0.33) | MEN1KMT2AHTTALDH1A1THRB | |
| SCHEMBL1911093 | 0.80 | ALDH1A1 (0.33) | MEN1KMT2AHTTALDH1A1THRB | |
| SCHEMBL1910829 | 0.80 | ALDH1A1 (0.33) | MEN1KMT2AHTTALDH1A1PRKCQ | |
| SCHEMBL14902741 | 0.80 | MEN1 (0.37) | MEN1KMT2A | |
| SCHEMBL10278570 | 0.79 | ALDH1A1 (0.34) | MEN1KMT2AHTTALDH1A1PRKCQ | |
| SCHEMBL1911125 | 0.78 | MEN1 (0.39) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |