Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5037308 | 0.77 | KDM4E (0.47) | JAK2TYK2ALDH1A1 | |
| SCHEMBL2645239 | 0.72 | HCAR3 (0.49) | HCAR3ALDH1A1 | |
| SCHEMBL2644724 | 0.68 | ALOX5AP (0.33) | HCAR3 | |
| SCHEMBL5040443 | 0.67 | L3MBTL1 (0.50) | ALDH1A1 | |
| SCHEMBL16680902 | 0.66 | MEN1 (0.36) | — | |
| SCHEMBL14390105 | 0.65 | — | — | |
| SCHEMBL20714407 | 0.63 | MAPT (0.52) | ALDH1A1 | |
| SCHEMBL4253816 | 0.63 | — | — | |
| SCHEMBL5044824 | 0.62 | HCAR3 (0.43) | JAK2JAK3HCAR3 | |
| SCHEMBL16388495 | 0.62 | IKBKE (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020008-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-02-16 | — | — | WO | disclosed |