Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | FABP3 | P05413 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12631313 | 0.89 | TRPM8 (0.35) | DPP4TAAR1MAOBTRPM8DCLRE1B | |
| SCHEMBL2013729 | 0.84 | TRPM8 (0.38) | TAAR1TRPM8DCLRE1BMAP4K4PTPN11 | |
| SCHEMBL15621481 | 0.77 | TRPM8 (0.40) | MAOBTRPM8DCLRE1BMAOASCN9A | |
| SCHEMBL10278951 | 0.77 | DPP4 (0.40) | DPP4TAAR1 | |
| SCHEMBL2163776 | 0.76 | KDM4E (0.41) | MAOBTRPM8DCLRE1BMAOASCN9A | |
| SCHEMBL2017243 | 0.74 | GRIA2 (0.40) | MAOBTRPM8MAOAMAP4K4 | |
| SCHEMBL2012705 | 0.74 | GRIA2 (0.40) | MAOBTRPM8MAOAMAP4K4 | |
| SCHEMBL9928745 | 0.74 | CSNK1E (0.41) | TRPM8MAP4K4PTPN11NQO2 | |
| SCHEMBL9928695 | 0.73 | TRPM8 (0.38) | MAOBTRPM8DCLRE1BMAOASCN9A | |
| SCHEMBL10278723 | 0.73 | NQO2 (0.43) | TRPM8MAP4K4PTPN11SCN9ANQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |