⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5041270 | 0.74 | — | — | |
| SCHEMBL2386792 | 0.74 | — | — | |
| SCHEMBL1590685 | 0.74 | — | — | |
| SCHEMBL436536 | 0.74 | — | — | |
| SCHEMBL4147815 | 0.72 | NPC1 (0.66) | — | |
| SCHEMBL9570044 | 0.71 | ALDH1A1 (0.53) | — | |
| SCHEMBL12631459 | 0.70 | SMN1; SMN2 (0.52) | — | |
| SCHEMBL4764484 | 0.69 | NPC1 (0.56) | — | |
| SCHEMBL12338477 | 0.69 | ALDH1A1 (0.53) | — | |
| SCHEMBL14536391 | 0.69 | SMN1; SMN2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468752-A1 | Thiazolopyridine derivatives as sirtuin-modulators | Sirtris Pharmaceuticals, Inc. (US) | 2012-06-27 | — | — | EP | disclosed |
| EP-2388263-A1 | Imidazo[2,1-b]thiazole derivatives as sirtuin modulators | Sirtris Pharmaceuticals, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| WO-2010011331-A2 | COMPOSITIONS AND METHODS RELATED TO SIRT1 FUNCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-01-28 | — | — | WO | disclosed |
| WO-2009053378-A1 | PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-IMIDAZO [2,1-B] THIAZOLE-5-SULFONYL HALIDE | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-04-30 | — | — | WO | disclosed |
| WO-2007008895-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-01-18 | — | — | WO | disclosed |