Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10780145 | 0.85 | TSHR (0.41) | TSHRPRKCITAS1R3TAS1R1RAB9A | |
| SCHEMBL4320180 | 0.80 | TSHR (0.68) | TSHRPRKCIRAB9ACTNNB1WNT3A | |
| SCHEMBL30344379 | 0.80 | TSHR (0.68) | TSHRPRKCIRAB9ACTNNB1WNT3A | |
| SCHEMBL837226 | 0.80 | TAS1R3 (0.43) | TSHRTAS1R3TAS1R1RAB9AALDH1A1 | |
| SCHEMBL1182047 | 0.79 | KDM4E (0.60) | TSHRPRKCITAS1R3TAS1R1RAB9A | |
| SCHEMBL20364677 | 0.79 | CTNNB1 (0.50) | TAS1R3TAS1R1RAB9AALDH1A1HPGD | |
| SCHEMBL4685014 | 0.77 | ALDH1A1 (0.55) | TSHRPRKCIRAB9AALDH1A1NPC1 | |
| SCHEMBL29463151 | 0.76 | ALDH1A1 (0.59) | RAB9AALDH1A1HPGDCTNNB1WNT3A | |
| SCHEMBL19932401 | 0.76 | TSHR (0.47) | TSHRPRKCITAS1R3TAS1R1RAB9A | |
| SCHEMBL10781619 | 0.75 | ATM (0.69) | TSHRTAS1R3TAS1R1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102169-B1 | INDAZOLYL AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2012-06-20 | — | — | EP | disclosed |
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |