Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31153188 | 1.00 | MAPT (0.50) | MAPTABCC4ALDH1A1USP2CYP3A4 | |
| SCHEMBL28680597 | 1.00 | MAPT (0.50) | MAPTABCC4ALDH1A1USP2CYP3A4 | |
| SCHEMBL31153192 | 0.98 | MAPT (0.47) | MAPTABCC4ALDH1A1USP2CYP3A4 | |
| SCHEMBL2805648 | 0.92 | MAPT (0.43) | MAPTABCC4ALDH1A1USP2CYP3A4 | |
| SCHEMBL4452846 | 0.89 | GPR84 (0.37) | MAPTABCC4TSHRGPR84SLC6A2 | |
| SCHEMBL6024755 | 0.84 | MAPT (0.45) | MAPTABCC4ALDH1A1USP2CYP3A4 | |
| SCHEMBL29954791 | 0.83 | ABCC4 (0.37) | MAPTABCC4TSHRDDAH1SLC6A2 | |
| SCHEMBL29951951 | 0.83 | ABCC4 (0.37) | MAPTABCC4TSHRDDAH1SLC6A2 | |
| SCHEMBL11512450 | 0.81 | MAPT (0.56) | MAPTABCC4ALDH1A1USP2CYP3A4 | |
| SCHEMBL7088338 | 0.81 | MAPT (0.56) | MAPTABCC4ALDH1A1USP2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2407470-A2 | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication | F. Hoffmann-La Roche Ltd. (CH) | 2012-01-18 | — | — | EP | disclosed |