Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 5/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.66 |
| ▸ | FLT3 | P36888 | 2/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.63 |
| ▸ | KDR | P35968 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1028117 | 0.87 | PDGFRB (0.61) | KITPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL1029982 | 0.82 | PDGFRB (0.61) | KITPDGFRAPDGFRBALDH1A1LMNA | |
| SCHEMBL1032702 | 0.80 | PDGFRB (0.65) | KITPDGFRAFLT3PDGFRBKDR | |
| Amuvatinib SCHEMBL29431554 | 0.79 | KIT (1.00) | KITPDGFRAFLT3PDGFRBKDR | |
| Amuvatinib SCHEMBL29351463 | 0.79 | KIT (1.00) | KITPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL15384140 | 0.79 | KIT (0.79) | KITPDGFRAFLT3PDGFRBKDR | |
| Amuvatinib SCHEMBL93976 | 0.79 | KIT (1.00) | KITPDGFRAFLT3PDGFRBKDR | |
| Amuvatinib SCHEMBL29883318 | 0.79 | KIT (1.00) | KITPDGFRAFLT3PDGFRBKDR | |
| Amuvatinib SCHEMBL1686091 | 0.79 | KIT (1.00) | KITPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL2387430 | 0.79 | PDGFRA (1.00) | KITPDGFRAFLT3PDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067123-B1 | NITROGENOUS HETEROCYCLIC COMPOUNDS | KYOWA HAKKO KIRIN CO LTD (JP) | 2011-01-19 | — | — | EP | disclosed |
| US-6423716-B1 | Nitrogenous heterocyclic compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-07-23 | — | — | US | disclosed |
| EP-1067123-A1 | NITROGENOUS HETEROCYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-01-10 | — | — | EP | disclosed |