Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.53 |
| ▸ | CDC25B | P30305 | 5/20 | 0.53 |
| ▸ | ACP1 | P24666 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22324065 | 0.78 | PTPN1 (0.50) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL875613 | 0.77 | PTPN1 (0.49) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL12550660 | 0.76 | PTPN1 (0.45) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL20351495 | 0.76 | PTPN1 (0.56) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL14194487 | 0.76 | PTPN1 (0.57) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL17748526 | 0.76 | PTPN1 (0.56) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL8194669 | 0.74 | PTPN1 (0.59) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL20826561 | 0.74 | PTPN1 (0.86) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL7114676 | 0.74 | PTPN1 (0.74) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL1410031 | 0.74 | PTPN1 (0.73) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3469907-B1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS INC (US) | 2021-03-03 | — | — | EP | disclosed |
| US-20190315696-A1 | ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF | API CORPORATION (JP) | 2019-10-17 | — | — | US | disclosed |
| US-10377722-B2 | Rosuvastatin calcium and process for producing intermediate thereof | API CORPORATION (JP) | 2019-08-13 | — | — | US | disclosed |
| US-20170305867-A1 | ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF | API CORPORATION (JP) | 2017-10-26 | — | — | US | disclosed |
| US-20170305867-A1 | ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF | API CORPORATION (JP) | 2017-10-26 | — | — | US | disclosed |
| US-9695130-B2 | Rosuvastatin calcium and process for producing intermediate thereof | API CORPORATION (JP) | 2017-07-04 | — | — | US | disclosed |
| US-9695130-B2 | Rosuvastatin calcium and process for producing intermediate thereof | API CORPORATION (JP) | 2017-07-04 | — | — | US | disclosed |
| EP-3103878-A1 | ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF | API Corporation (JP) | 2016-12-14 | — | — | EP | disclosed |
| US-20160347718-A1 | ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF | API CORPORATION (JP) | 2016-12-01 | — | — | US | disclosed |
| US-20160347718-A1 | ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF | API CORPORATION (JP) | 2016-12-01 | — | — | US | disclosed |
| WO-2007122591-A2 | PYRAZOLO-TETRAHYDRO PYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007001335-A2 | RAMOPLANIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY | VICURON PHARMACEUTICALS INC. (US) | 2007-01-04 | — | — | WO | disclosed |
| US-20060211603-A1 | Ramoplanin derivatives possessing antibacterial activity | VICURON PHARMACEUTICALS INC. (US) | 2006-09-21 | — | — | US | disclosed |
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |
| US-7067540-B2 | Substituted pyridinones | PHARMACIA CORPORATION (US) | 2006-06-27 | — | — | US | disclosed |
| US-20050176775-A1 | Substituted pyridinones | PHARMACIA CORPORATION | 2005-08-11 | — | — | US | disclosed |
| WO-2005018557-A2 | SUBSTITUTED PYRIDINONES | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| EP-1490064-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | Pharmacia Corporation (US) | 2004-12-29 | — | — | EP | disclosed |
| US-20040058964-A1 | Substituted pyridinones | PHARMACIA LLC | 2004-03-25 | — | — | US | disclosed |
| WO-2003068230-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORPORATION (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160347718-A1 | ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF | HMGCR, COASY, PCSK9 | PTPN1 4202/4885CDC25B 3842/4885ACP1 479/4885 |
| US-20170305867-A1 | ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF | HMGCR, COASY, PCSK9 | PTPN1 4202/4885CDC25B 3842/4885ACP1 479/4885 |
| US-20040058964-A1 | Substituted pyridinones | MAPK1, MAPK6, MAPK7 | PTPN1 361/4885CDC25B 378/4885ACP1 171/4885 |
| US-10377722-B2 | Rosuvastatin calcium and process for producing intermediate thereof | HMGCR, COASY, PCSK9 | PTPN1 4202/4885CDC25B 3842/4885ACP1 479/4885 |
| US-20190315696-A1 | ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF | HMGCR, COASY, PCSK9 | PTPN1 4202/4885CDC25B 3842/4885ACP1 479/4885 |
| US-20060211603-A1 | Ramoplanin derivatives possessing antibacterial activity | CLSPN, LMAN2, RPN2 | PTPN1 2060/4885CDC25B 649/4885ACP1 522/4885 |
| US-20050176775-A1 | Substituted pyridinones | MAPK1, MAPK6, MAP3K6 | PTPN1 571/4885CDC25B 564/4885ACP1 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.