Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.50 |
| ▸ | CDC25B | P30305 | 5/20 | 0.50 |
| ▸ | ACP1 | P24666 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8027682 | 0.84 | PTPN1 (0.47) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL1028277 | 0.78 | PTPN1 (0.53) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL1356857 | 0.75 | PTPN1 (0.62) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL12965215 | 0.74 | PTPN1 (0.49) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL12550660 | 0.73 | PTPN1 (0.45) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL20351495 | 0.73 | PTPN1 (0.56) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL14194487 | 0.73 | PTPN1 (0.57) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL17748526 | 0.73 | PTPN1 (0.56) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL20826561 | 0.72 | PTPN1 (0.86) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 | |
| SCHEMBL7114676 | 0.72 | PTPN1 (0.74) | PTPN1CDC25BACP1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11964971-B2 | Methods and compositions for modulating splicing | SKYHAWK THERAPEUTICS, INC. (US) | 2024-04-23 | — | — | US | disclosed |
| US-20230068499-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2023-03-02 | — | — | US | disclosed |
| EP-3920928-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | Skyhawk Therapeutics, Inc. (US) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020163544-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. (US) | 2020-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11964971-B2 | Methods and compositions for modulating splicing | RBM17, SF3B1, SF3B5 | PTPN1 4172/4885CDC25B 3775/4885ACP1 2108/4885 |
| US-20230068499-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | RBM17, SF3B1, SF3B5 | PTPN1 4172/4885CDC25B 3775/4885ACP1 2108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.