Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12002154 | 0.90 | KCNH2 (0.44) | KCNH2HTR1A | |
| SCHEMBL10285621 | 0.86 | OPRM1 (0.39) | KCNH2OPRM1HTR2ATHRBNR1H4 | |
| SCHEMBL10285204 | 0.83 | KCNH2 (0.42) | KCNH2OPRM1HTR2ATHRB | |
| SCHEMBL10285571 | 0.82 | CNR2 (0.41) | KCNH2OPRM1THRB | |
| SCHEMBL12000152 | 0.82 | KCNH2 (0.36) | KCNH2GPR119THRB | |
| SCHEMBL2798129 | 0.81 | KCNH2 (0.47) | KCNH2OPRM1HTR1A | |
| SCHEMBL14279787 | 0.81 | CNR2 (0.45) | KCNH2OPRM1 | |
| SCHEMBL10285574 | 0.80 | KCNH2 (0.37) | KCNH2OPRM1HTR2ATHRBNR1H4 | |
| SCHEMBL10285209 | 0.79 | KCNH2 (0.37) | KCNH2HTR2ANR1H4 | |
| SCHEMBL12002169 | 0.79 | KCNH2 (0.44) | KCNH2OPRM1HTR1ANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468743-A1 | Nitrogen-containing bicyclic compounds useful as antibacterial agents | Toyama Chemical Co., Ltd. (JP) | 2012-06-27 | — | — | EP | disclosed |