Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 7/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20824821 | 0.85 | CYP2A6 (0.37) | CYP2A6HTR6CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL30940058 | 0.81 | CYP2A6 (0.58) | CYP2A6RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL30459098 | 0.81 | CYP2A6 (0.47) | CYP2A6HTR6RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL19225672 | 0.81 | CYP2A6 (0.44) | CYP2A6 | |
| SCHEMBL25030031 | 0.78 | HTR6 (0.52) | CYP2A6HTR6CYP2D6CYP3A4 | |
| SCHEMBL25029772 | 0.75 | CYP2A6 (0.39) | CYP2A6HTR6CYP2D6CYP3A4 | |
| SCHEMBL14438020 | 0.75 | CYP2A6 (0.51) | CYP2A6CYP2E1CYP2D6CYP2B6CYP2C19 | |
| SCHEMBL25030040 | 0.74 | HTR6 (0.39) | CYP2A6HTR6CYP2D6CYP3A4 | |
| SCHEMBL91157 | 0.72 | CYP2A6 (0.67) | CYP2A6ALDH1A1SMN1; SMN2 | |
| SCHEMBL3962397 | 0.72 | CYP2A6 (0.53) | CYP2A6RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-B1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARM INC (US) | 2017-06-21 | — | — | EP | disclosed |
| US-9359375-B2 | Benzamides and nicotinamides as Syk modulators | PORTOLA PHARMACEUTICALS, INC. (US) | 2016-06-07 | — | — | US | disclosed |