SCHEMBL3962397

SCHEMBL3962397

Brc1csc2ccncc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 5/20 0.53
AXL P30530 1/20 0.42
IMPDH2 P12268 1/20 0.33
ALDH1A1 P00352 2/20 0.33
RAB9A P51151 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
CCNT1 O60563 1/20 0.33
PIM1 P11309 1/20 0.33
CDK9 P50750 1/20 0.33
HASPIN Q8TF76 1/20 0.33
CYP19A1 P11511 2/20 0.32
POLB P06746 1/20 0.32
KDM4E B2RXH2 2/20 0.32
HTT P42858 1/20 0.32
NCOA1 Q15788 1/20 0.32
NCOA3 Q9Y6Q9 1/20 0.32
ACHE P22303 1/20 0.31
LMNA P02545 2/20 0.31
CHUK O15111 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30940059 1.00 CYP2A6 (0.53) CYP2A6AXLIMPDH2ALDH1A1RAB9A
SCHEMBL658960 0.83 AXL (0.42) CYP2A6AXLIMPDH2ALDH1A1CCNT1
SCHEMBL1006461 0.77 CYP2A6 (0.56) CYP2A6AXLIMPDH2ALDH1A1POLB
SCHEMBL28913407 0.77 CYP2A6 (0.51) CYP2A6ALDH1A1RAB9ASMN1; SMN2PIM1
SCHEMBL31167180 0.77 CYP2A6 (0.56) CYP2A6AXLIMPDH2ALDH1A1POLB
SCHEMBL14438020 0.77 CYP2A6 (0.51) CYP2A6ALDH1A1RAB9ASMN1; SMN2CYP19A1
SCHEMBL31751996 0.76 CYP2A6 (0.47) CYP2A6ALDH1A1RAB9ASMN1; SMN2CHUK
SCHEMBL18878988 0.72 CYP2A6 (0.47) CYP2A6ALDH1A1RAB9ASMN1; SMN2POLB
SCHEMBL194929 0.72 CYP2A6 (0.47) CYP2A6ALDH1A1RAB9ASMN1; SMN2CYP19A1
SCHEMBL10285458 0.72 CYP2A6 (0.47) CYP2A6ALDH1A1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240409542-A1 NOVEL COMPOUNDS SITRYX THERAPEUTICS LIMITED (GB) 2024-12-12 US disclosed
EP-4408845-A1 NOVEL COMPOUNDS Sitryx Therapeutics Limited (GB) 2024-08-07 EP disclosed
US-20240208912-A1 MTA-Cooperative PRMT5 Inhibitors MIRATI THERAPEUTICS INC (US) 2024-06-27 US disclosed
US-20240208912-A1 MTA-Cooperative PRMT5 Inhibitors MIRATI THERAPEUTICS INC (US) 2024-06-27 US disclosed
CN-118139864-A New compounds 西特瑞治疗有限公司 2024-06-04 CN disclosed
EP-4304720-A1 MTA-COOPERATIVE PRMT5 INHIBITORS Mirati Therapeutics, Inc. (US) 2024-01-17 EP disclosed
WO-2023052783-A1 NOVEL COMPOUNDS SITRYX THERAPEUTICS LIMITED (GB) 2023-04-06 WO disclosed
WO-2022192745-A1 MTA-COOPERATIVE PRMT5 INHIBITORS Mirati Therapeutics, Inc. (US) 2022-09-15 WO disclosed
US-20170283429-A1 COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS Janssen Biopharma, Inc. 2017-10-05 US disclosed
US-20170283429-A1 COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS Janssen Biopharma, Inc. 2017-10-05 US disclosed
US-9724351-B2 Compounds for the treatment of paramoxyvirus viral infections ALIOS BIOPHARMA, INC. (US) 2017-08-08 US disclosed
US-20150238498-A1 COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS JANSSEN PHARMACEUTICA NV (BE) 2015-08-27 US disclosed
US-20150238498-A1 COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS JANSSEN PHARMACEUTICA NV (BE) 2015-08-27 US disclosed
WO-2015076600-A1 NOVEL LIGHT EMISSION COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME 주식회사 동진쎄미켐 2015-05-28 WO disclosed
WO-2014031784-A1 COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS ALIOS BIOPHARMA, INC. (US) 2014-02-27 WO disclosed
US-7557103-B2 Imidazopyridazine compounds ELI LILLY AND COMPANY (US) 2009-07-07 US disclosed
US-20080153828-A1 Imidazopyridazine Compounds ELI LILLY AND COMPANY 2008-06-26 US disclosed
EP-1879896-A1 IMIDAZOPYRIDAZINE COMPOUNDS ELI LILLY AND COMPANY (US) 2008-01-23 EP disclosed
WO-2006107784-A1 IMIDAZOPYRIDAZINE COMPOUNDS ELI LILLY AND COMPANY (US) 2006-10-12 WO disclosed
US-4902694-A TREATING CONGESTIVE HEART FAILURE ELI LILLY AND COMPANY (US) 1990-02-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150238498-A1 COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS SARS1, MAVS, ZC3HAV1 CYP2A6 4205/4885AXL 4536/4885IMPDH2 1725/4885
US-20170283429-A1 COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS MAVS, SARS1, ZC3HAV1 CYP2A6 4442/4885AXL 4461/4885IMPDH2 1491/4885
US-20080153828-A1 Imidazopyridazine Compounds CRHR1, CRH, CRHR2 CYP2A6 1079/4885AXL 1429/4885IMPDH2 1995/4885
US-20240208912-A1 MTA-Cooperative PRMT5 Inhibitors PRMT1, PRMT5, PRMT6 CYP2A6 4345/4885AXL 4017/4885IMPDH2 351/4885
US-20240409542-A1 NOVEL COMPOUNDS CD47, GPR119, LRBA CYP2A6 931/4885AXL 4218/4885IMPDH2 3054/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.