Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.44 |
| ▸ | DPP4 | P27487 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | HEXA | P06865 | 1/20 | 0.36 |
| ▸ | HEXB | P07686 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10286259 | 0.94 | RAB9A (0.52) | RAB9AMAPTMAPK1ADORA2APIK3CD | |
| SCHEMBL4169571 | 0.89 | MAPT (0.48) | RAB9AMAPTMAPK1PIK3CDDPP4 | |
| SCHEMBL4174724 | 0.83 | PIK3CD (0.52) | RAB9AMAPTMAPK1PIK3CDDPP4 | |
| SCHEMBL10285462 | 0.76 | DPP4 (0.39) | RAB9AMAPTMAPK1ADORA2APIK3CD | |
| SCHEMBL4178860 | 0.76 | DPP4 (0.44) | RAB9APIK3CDDPP4NPC1ALDH1A1 | |
| SCHEMBL13973986 | 0.74 | MAPT (0.48) | RAB9AMAPTMAPK1PIK3CDALDH1A1 | |
| SCHEMBL1598282 | 0.74 | MAPT (0.48) | RAB9AMAPTMAPK1PIK3CDPIM1 | |
| SCHEMBL19788621 | 0.73 | DPP4 (0.41) | PIK3CDDPP4ALDH1A1DPP8 | |
| SCHEMBL4184546 | 0.73 | PIK3CD (0.55) | PIK3CDATM | |
| SCHEMBL10286281 | 0.72 | PIK3CD (0.54) | RAB9AMAPTMAPK1PIK3CDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193199-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2012-06-05 | — | — | US | disclosed |
| US-20090137581-A1 | Heterocyclic compounds and their uses | AMGEN INC. | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137581-A1 | Heterocyclic compounds and their uses | MCL1, BCL9, MALT1 | RAB9A 2240/4885MAPT 3355/4885MAPK1 1094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.