Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4169580 | 0.84 | DPP4 (0.40) | DPP4PIK3CDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10286259 | 0.82 | RAB9A (0.52) | DPP4PIK3CDADORA2ARAB9ANPC1 | |
| SCHEMBL4174475 | 0.79 | DPP4 (0.40) | DPP4RAB9ANPC1ALDH1A1GAA | |
| SCHEMBL10286273 | 0.76 | RAB9A (0.52) | DPP4PIK3CDADORA2ARAB9ANPC1 | |
| SCHEMBL19788607 | 0.74 | DPP4 (0.39) | DPP4PIK3CDGAAMGAMSI | |
| SCHEMBL21705888 | 0.74 | MBNL1 (0.39) | DPP4PIK3CDADORA2AMBNL1RAB9A | |
| SCHEMBL4174724 | 0.72 | PIK3CD (0.52) | DPP4PIK3CDRAB9ANPC1ALDH1A1 | |
| SCHEMBL13973988 | 0.72 | MBNL1 (0.43) | PIK3CDADORA2AMBNL1RAB9ANPC1 | |
| SCHEMBL4174814 | 0.71 | KDM4E (0.37) | DPP4PIK3CDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4179102 | 0.69 | DPP4 (0.40) | DPP4PIK3CDADORA2AMBNL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193199-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2012-06-05 | — | — | US | disclosed |
| US-20090137581-A1 | Heterocyclic compounds and their uses | AMGEN INC. | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137581-A1 | Heterocyclic compounds and their uses | MCL1, BCL9, MALT1 | DPP4 4588/4885PIK3CD 16/4885ADORA2A 1368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.