Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3262344 | 0.86 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL237417 | 0.81 | CYP1A2 (0.55) | NPC1RAB9ASMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL2755207 | 0.81 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL2755168 | 0.80 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL2755218 | 0.79 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL3253086 | 0.77 | PKM (0.32) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2755116 | 0.76 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL2755224 | 0.75 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL2755212 | 0.75 | RAB9A (0.65) | NPC1RAB9ASMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL2755219 | 0.74 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | PIK3CD, PIK3CA, PIK3R5 | NPC1 1127/4885RAB9A 778/4885SMN1; SMN2 3442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.