Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1017814 | 0.89 | ALB (0.49) | TRPV1GRM4 | |
| SCHEMBL26035513 | 0.89 | TRPV1 (0.47) | TRPV1 | |
| SCHEMBL13628633 | 0.85 | TRPV1 (0.43) | TRPV1GRM4 | |
| SCHEMBL10287501 | 0.85 | TRPV1 (0.46) | TRPV1GRM4 | |
| SCHEMBL12215504 | 0.84 | KCNK3 (0.50) | TRPV1GRM4 | |
| SCHEMBL10287561 | 0.84 | TGFBR1 (0.45) | TRPV1GRM4 | |
| SCHEMBL12918728 | 0.83 | ALB (0.51) | CES1GRM4 | |
| SCHEMBL12918726 | 0.83 | TRPV1 (0.46) | TRPV1 | |
| SCHEMBL12214421 | 0.82 | PAX8 (0.43) | TRPV1GRM4 | |
| SCHEMBL2619320 | 0.82 | MAPK14 (0.44) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094980-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GUNZNER JANET L (US) | 2012-04-19 | — | — | US | disclosed |
| US-7888364-B2 | Pyridyl inhibitors of hedgehog signalling | CURIS, INC. (US) | 2011-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094980-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | TRPV1 4209/4885CES1 4187/4885GRM4 1839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.