Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | TPH1 | P17752 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627366 | 0.86 | PIK3CA (0.40) | PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL10298513 | 0.86 | PDE10A (0.34) | PDE10APRKDCCETP | |
| SCHEMBL626480 | 0.80 | NPC1 (0.37) | PDE10APRKDCCETPALDH1A1HPGD | |
| SCHEMBL10288131 | 0.75 | HSD17B10 (0.42) | PDE10ATPH1PRKDCKDM4EALDH1A1 | |
| SCHEMBL10298533 | 0.69 | KDM4E (0.32) | KDM4EALDH1A1MAPTPIK3CA | |
| SCHEMBL952623 | 0.68 | MPO (0.37) | PDE10ACETPCYP2D6NFKB1TAAR1 | |
| SCHEMBL10288613 | 0.65 | TRPV1 (0.37) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL16850491 | 0.65 | PDE10A (0.41) | PDE10ACETPALDH1A1PIK3CAPIK3CD | |
| SCHEMBL623933 | 0.64 | PIK3CA (0.52) | TPH1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL10298521 | 0.64 | AKR1C3 (0.38) | PDE10ATPH1PRKDCKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021696-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |