Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16510466 | 0.81 | CA12 (0.65) | CYP1A2ALDH1A1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL13100051 | 0.81 | LMNA (0.52) | CYP1A2ALDH1A1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL6409033 | 0.81 | CYP2C9 (0.66) | CYP1A2HSP90AA1HSP90AB1BLMALDH1A1 | |
| SCHEMBL16510467 | 0.80 | TSHR (0.46) | CYP1A2ALDH1A1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL12139942 | 0.78 | HPGD (0.43) | HSP90AA1ERN1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1545307 | 0.78 | CYP1A2 (0.69) | CYP1A2HSP90AA1HSP90AB1BLMERN1 | |
| SCHEMBL17151146 | 0.78 | CYP1A2 (0.47) | CYP1A2HSP90AA1HSP90AB1BLMERN1 | |
| SCHEMBL15020075 | 0.77 | ALDH1A1 (0.50) | CYP1A2HSP90AA1HSP90AB1BLMERN1 | |
| SCHEMBL358787 | 0.77 | ALDH1A1 (0.50) | CYP1A2HSP90AA1HSP90AB1BLMERN1 | |
| SCHEMBL14059590 | 0.75 | ERN1 (0.48) | CYP1A2HSP90AA1HSP90AB1BLMERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023589-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | HOFFMANN-LA ROCHE INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | ARORA NIDHI (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023589-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | IRAK4, IRAK1, IRAK2 | CYP1A2 3515/4885HSP90AA1 3693/4885HSP90AB1 3712/4885 |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | CYP1A2 3515/4885HSP90AA1 3693/4885HSP90AB1 3712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.