Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10288574 | 0.91 | HPGD (0.38) | PIK3CAPIK3R1MTORHPGDMAPK1 | |
| SCHEMBL10308557 | 0.87 | HPGD (0.36) | PIK3CAPIK3CGPIK3R1PIK3CDPIK3CB | |
| SCHEMBL10288604 | 0.84 | PIK3CA (0.48) | PIK3CAPIK3CGPIK3R1PIK3CDPIK3CB | |
| SCHEMBL10288409 | 0.81 | ALDH1A1 (0.37) | PIK3CAPIK3CGPIK3R1PIK3CDPIK3CB | |
| SCHEMBL10288572 | 0.79 | KDM4E (0.38) | PIK3CAPIK3CGPIK3R1PIK3CDPIK3CB | |
| SCHEMBL10288594 | 0.78 | ALDH1A1 (0.36) | PIK3CAPIK3CGPIK3R1PIK3CDPIK3CB | |
| SCHEMBL10288607 | 0.77 | SLC6A2 (0.36) | PIK3CAPIK3R1HPGDMAPK1NPSR1 | |
| SCHEMBL10308588 | 0.77 | HPGD (0.38) | PIK3CAHPGDMAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL10288191 | 0.76 | PIK3CA (0.35) | PIK3CAPIK3R1HPGDMAPK1NPSR1 | |
| SCHEMBL625724 | 0.75 | PIK3CA (0.49) | PIK3CAPIK3R1PIK3CDPIK3CBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021696-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |