Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10257754 | 0.89 | RORC (0.54) | RORCMEN1KMT2AALDH1A1GAA | |
| SCHEMBL512342 | 0.79 | RORC (0.49) | RORCMEN1KMT2AALDH1A1GAA | |
| SCHEMBL12685516 | 0.79 | TACR1 (0.45) | MEN1KMT2AALDH1A1GAANPSR1 | |
| SCHEMBL14373288 | 0.68 | RORC (0.55) | RORCMEN1KMT2AALDH1A1GAA | |
| SCHEMBL10258473 | 0.68 | TACR1 (0.48) | MEN1KMT2AALDH1A1GAANPSR1 | |
| SCHEMBL12685539 | 0.68 | SIGMAR1 (0.45) | MEN1KMT2AALDH1A1MAPTDRD4 | |
| SCHEMBL512741 | 0.68 | RORC (0.50) | RORCMEN1KMT2AALDH1A1GAA | |
| SCHEMBL16830552 | 0.67 | RORC (1.00) | RORC | |
| SCHEMBL14373268 | 0.67 | RORC (0.56) | RORCMEN1KMT2AALDH1A1GAA | |
| SCHEMBL28169051 | 0.66 | TP53 (0.50) | MEN1KMT2AALDH1A1GAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012103297-A1 | COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-08-02 | — | — | WO | disclosed |
| WO-2011014535-A1 | COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-02-03 | — | — | WO | disclosed |